Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
1.
Arq. bras. med. vet. zootec. (Online) ; 72(6): 2271-2278, Nov.-Dec. 2020. ilus
Article in Portuguese | VETINDEX, LILACS | ID: biblio-1142300

ABSTRACT

Relata-se um caso de melanoma oral disseminado em uma cadela de dois anos, com protrusão de bulbo ocular unilateral e quadro convulsivo progressivo. Os exames de imagem revelaram aumento de volume nas regiões submandibular, maxilar e cerebral, padrão nodular pulmonar e aumento das dimensões ovarianas. A citologia da massa submandibular indicou proliferação epitelial maligna, enquanto a biópsia excisional foi sugestiva de melanoma amelanótico. Na necropsia, havia uma massa gengival localmente infiltrativa e nodulações brancas nos linfonodos, nos rins, no pulmão, no cérebro e nos ovários, indicativas de metástase. O diagnóstico histopatológico consistiu de neoplasia maligna metastática indiferenciada, indicativo de melanoma amelanótico. Células caracterizadas por núcleo com cromatina espessa, múltiplos nucléolos bem evidentes, mitoses atípicas e multinucleações consistiram nos principais critérios de malignidade. No espaço peritrabecular ósseo facial, havia rara diferenciação pigmentar melanocítica, confirmada histoquimicamente pela técnica de Fontana-Massom e Giemsa. Algumas células foram positivas pela imuno-histoquímica para PNL-2 e Melan-A, e o diagnóstico de melanoma amelanótico disseminado foi firmado. A indiferenciação neoplásica marcante, com disseminação metastática multissistêmica e acometimento mútuo de sítios anatômicos pouco comuns, conjuntamente com a ampla variação dos padrões celulares, foi responsável pelo desafio diagnóstico do presente caso, ressaltando o papel decisivo da imuno-histoquímica para confirmação diagnóstica. A importância clínica deste trabalho consiste ainda em alertar a comunidade clínica e científica acerca da dificuldade diagnóstica, devendo-se considerar o melanoma amelanótico como diferencial mesmo em casos de lesões orais menos perceptíveis e/ou desprovidas de pigmentação.(AU)


A case of disseminated oral melanoma in a two year old female dog with unilateral protuberance of the eye bulb and progressive seizure is described. Imaging exams revealed increase of the submandibular, maxillary and cerebral regions, nodular pattern in lungs and increased ovarian dimensions. The cytology of the submandibular mass indicated a malignant epithelial proliferation, whereas the excisional biopsy indicated an amelanotic melanoma. At necropsy, a locally infiltrating gingival mass and white nodules in the lymph nodes, kidneys, lung, brain and ovaries were observed, indicative of metastases. Histopathological diagnosis consisted of an undifferentiated malignant metastatic neoplasm. Nucleus with coarse chromatin, prominent nucleoli, bizarre mitotic figures and multinucleated cells were the major malignant features. There was a poor melanocytic pigment differentiation in the peritrabecular space of facial bones, confirmed by Fontana-Masson and Giemsa histochemical techniques. Only a few cells were immunohistochemically positive for PNL-2 and Melan-A and the diagnosis of a disseminated amelanotic melanoma was performed. The diagnostic challenge was based on marked neoplastic undifferentiation, with multisystemic metastasis and mutual involvement of uncommon anatomic sites, associated with a large variability of cellular patterns, highlighting the decisive role of immunohistochemistry for diagnostic confirmation. Therefore, the clinical importance of this study is to warn the clinical and scientific community about the diagnostic challenge, considering the amelanotic melanoma as a differential even in cases of poorly apparent and/or nonpigmented oral lesions.(AU)


Subject(s)
Animals , Female , Dogs , Mouth Neoplasms/veterinary , Melanoma, Amelanotic/complications , Melanoma, Amelanotic/veterinary , Ovarian Neoplasms/veterinary , Neoplasm Metastasis
2.
Indian J Ophthalmol ; 2008 Sep-Oct; 56(5): 421-3
Article in English | IMSEAR | ID: sea-69709

ABSTRACT

Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder of DNA repair in which the body's normal ability to repair damage caused by ultraviolet light is deficient. This leads to a 1000-fold increased risk of cutaneous and ocular neoplasms. Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma. Malignant melanomas occur at an early age in patients with XP. We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.


Subject(s)
Child , Diagnosis, Differential , Humans , Male , Melanoma, Amelanotic/complications , Ophthalmologic Surgical Procedures/methods , Orbit , Skin Neoplasms/complications , Xeroderma Pigmentosum/complications
3.
Arch. argent. dermatol ; 46(2): 53-63, mar.-abr. 1996. ilus, tab
Article in Spanish | LILACS | ID: lil-166467

ABSTRACT

Se presentan los hallazgos de un estudio retrospectivo, realizado con 109 pacientes portadores de melanoma maligno, diagnosticados en el Hospital Privado de Comunidad, de Mar del Plata, entre los años 1971-1991. Se constató una alta incidencia, del 0,04 por ciento de las consultas dermatológicas y del 0,001 por ciento de las consultas generales de dicho período de 20 años. Las edades estuvieron comprendidas entre los 25 y 93 años....


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Melanoma, Amelanotic/diagnosis , Melanoma/diagnosis , Melanoma, Amelanotic/complications , Melanoma, Amelanotic/diagnosis , Melanoma/classification , Melanoma/mortality , Neoplasm Staging/statistics & numerical data , Neoplasms by Site , Survival Rate
SELECTION OF CITATIONS
SEARCH DETAIL